diff --git a/src/octoprint/plugins/cura/static/js/cura.js b/src/octoprint/plugins/cura/static/js/cura.js
index 87f9d5f6..78b30bfd 100644
--- a/src/octoprint/plugins/cura/static/js/cura.js
+++ b/src/octoprint/plugins/cura/static/js/cura.js
@@ -24,6 +24,7 @@ $(function() {
         self.profileDescription = ko.observable();
         self.profileAllowOverwrite = ko.observable(true);
         self.profileMakeDefault = ko.observable(false);
+        self.profileFirst = ko.observable(false);
 
         // make sure to update form data if any of the metadata changes
         self.profileName.subscribe(function() { self.copyProfileMetadata(); });
@@ -134,7 +135,10 @@ $(function() {
             self.profileDisplayName(undefined);
             self.profileDescription(undefined);
             self.profileAllowOverwrite(true);
-            self.profileMakeDefault(false);
+
+            var firstProfile = self.profiles.items().length === 0;
+            self.profileMakeDefault(firstProfile);
+            self.profileFirst(firstProfile);
         };
 
         self.uploadElement.fileupload({
diff --git a/src/octoprint/plugins/cura/templates/snippets/settings/cura/profileImporter.jinja2 b/src/octoprint/plugins/cura/templates/snippets/settings/cura/profileImporter.jinja2
index 71ff1465..c2aee166 100644
--- a/src/octoprint/plugins/cura/templates/snippets/settings/cura/profileImporter.jinja2
+++ b/src/octoprint/plugins/cura/templates/snippets/settings/cura/profileImporter.jinja2
@@ -37,15 +37,15 @@
             </div>
             <div class="control-group">
                 <div class="controls">
-                    <label class="checkbox" data-bind="enable: fieldsEnabled, css: {disabled: !fieldsEnabled()}">
-                        <input type="checkbox" data-bind="checked: profileMakeDefault"> {{ _('Make default profile') }}
+                    <label class="checkbox">
+                        <input type="checkbox" data-bind="checked: profileMakeDefault, enable: fieldsEnabled() && !profileFirst(), css: {disabled: !fieldsEnabled() || profileFirst()}"> {{ _('Make default profile') }}
                     </label>
                 </div>
             </div>
             <div class="control-group">
                 <div class="controls">
-                    <label class="checkbox" data-bind="enable: fieldsEnabled, css: {disabled: !fieldsEnabled()}">
-                        <input type="checkbox" data-bind="checked: profileAllowOverwrite"> {{ _('Overwrite existing file') }}
+                    <label class="checkbox">
+                        <input type="checkbox" data-bind="checked: profileAllowOverwrite, enable: fieldsEnabled() && !profileFirst(), css: {disabled: !fieldsEnabled() || profileFirst()}"> {{ _('Overwrite existing file') }}
                     </label>
                 </div>
             </div>
diff --git a/src/octoprint/slicing/__init__.py b/src/octoprint/slicing/__init__.py
index a1546c0a..27ca5849 100644
--- a/src/octoprint/slicing/__init__.py
+++ b/src/octoprint/slicing/__init__.py
@@ -377,6 +377,10 @@ class SlicingManager(object):
 
 		If it's a :class:`dict`, a new :class:`SlicingProfile` instance will be created with the supplied meta data and
 		the profile data as the :attr:`~SlicingProfile.data` attribute.
+		
+		.. note::
+		
+		   If the profile is the first profile to be saved for the slicer, it will automatically be marked as default.
 
 		Arguments:
 		    slicer (str): Identifier of the slicer for which to save the ``profile``.
@@ -414,6 +418,8 @@ class SlicingManager(object):
 			if description is not None:
 				profile.description = description
 
+		first_profile = len(self.all_profiles(slicer, require_configured=False)) == 0
+
 		path = self.get_profile_path(slicer, name)
 		is_overwrite = os.path.exists(path)
 
@@ -426,6 +432,10 @@ class SlicingManager(object):
 		               profile=name)
 		event = octoprint.events.Events.SLICING_PROFILE_MODIFIED if is_overwrite else octoprint.events.Events.SLICING_PROFILE_ADDED
 		octoprint.events.eventManager().fire(event, payload)
+		
+		if first_profile:
+			# enforce the first profile we add for this slicer  is set as default
+			self.set_default_profile(slicer, name)
 
 		return profile